Poxvirus Exploitation of the Ubiquitin-Proteasome System
Author Information
Author(s): Barry Michele, van Buuren Nicholas, Mottet Kristin, Wang Kelly, Qian Teale, Alastair
Primary Institution: Department of Medical Microbiology and Immunology, University of Alberta
Hypothesis
Poxviruses have evolved various strategies to exploit the ubiquitin-proteasome system.
Conclusion
Poxviruses encode multiple proteins that manipulate the ubiquitin-proteasome system to regulate cellular processes.
Supporting Evidence
- Poxviruses encode proteins that manipulate the ubiquitin-proteasome system.
- Ubiquitin plays a critical role in many cellular processes.
- Proteasome inhibitors block poxvirus replication.
- Poxviruses have evolved strategies to evade the host immune response.
- Ubiquitin is associated with the virion in several viruses.
Takeaway
Poxviruses have special tricks to use a system in our cells that helps break down proteins, which helps them survive and replicate.
Methodology
This review describes the mechanisms that poxviruses use to manipulate the ubiquitin-proteasome system.
Limitations
The specific roles of many poxvirus proteins in the ubiquitin-proteasome system remain unclear.
Digital Object Identifier (DOI)
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