CYP1B1 Gene Polymorphism and Breast Cancer Risk in Nigerian Women
Author Information
Author(s): Okobia Michael N, Bunker Clareann H, Garte Seymour J, Zmuda Joseph M, Ezeome Emmanuel R, Anyanwu Stanley N C, Uche Emmanuel E O, Osime Usifo, Ojukwu Joseph, Kuller Lewis H, Ferrell Robert E, Taioli Emanuela
Primary Institution: University of Pittsburgh
Hypothesis
Does the CYP1B1 Val432Leu polymorphism increase breast cancer risk in Nigerian women?
Conclusion
The CYP1B1 gene polymorphism is linked to a higher risk of breast cancer, especially in premenopausal women of African descent.
Supporting Evidence
- Heterozygosity for the CYP1B1 M1 genotype was associated with a significant 59% increased risk of breast cancer.
- In premenopausal women, having at least one CYP1B1 (Leu) allele conferred a significant two-fold increased risk of breast cancer.
- No significant association was observed in postmenopausal women.
Takeaway
This study found that a specific gene change can make some women more likely to get breast cancer, especially younger women.
Methodology
A case-control study using PCR-based RFLP assay to analyze genetic polymorphisms in 500 women.
Potential Biases
Potential systematic bias due to recruitment methods and the nature of the control group.
Limitations
The use of hospital controls may introduce bias, and the study did not assess hormone receptor status.
Participant Demographics
500 women, 250 with breast cancer and 250 controls, matched by age and institution.
Statistical Information
P-Value
0.05
Confidence Interval
1.01–2.58
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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