Altered behavioral and metabolic circadian rhythms in mice with disrupted NAD+ oscillation
2011
NAD+ Levels Affect Circadian Rhythms in Mice
Sample size: 14
publication
Evidence: moderate
Author Information
Author(s): Sahar Saurabh, Nin Veronica, Barbosa Maria Thereza, Chini Eduardo Nunes, Sassone-Corsi Paolo
Primary Institution: University of California, Irvine
Hypothesis
Does NAD+ oscillation contribute to circadian physiology?
Conclusion
Elevated NAD+ levels in CD38-deficient mice disrupt circadian behavior and metabolism.
Supporting Evidence
- CD38-deficient mice have significantly higher NAD+ levels compared to wild-type mice.
- Altered circadian behavior was observed in CD38-null mice, including a shorter period length of locomotor activity.
- Several clock genes were deregulated in the livers of CD38-null mice.
Takeaway
Mice without a certain protein have too much NAD+, which messes up their body clock and how they use energy.
Methodology
The study analyzed circadian behavior and metabolism in CD38-deficient mice compared to wild-type mice.
Limitations
The study primarily focuses on male mice, which may limit the generalizability of the findings.
Participant Demographics
C57BL/6J.129 CD38−/− mice were used in the study.
Statistical Information
P-Value
0.008
Statistical Significance
p<0.05
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