How Trichinella spiralis Uses Paramyosin to Avoid Immune Attack
Author Information
Author(s): Zhang Zhifei, Yang Jing, Wei Junfei, Yang Yaping, Chen Xiaoqin, Zhao Xi Gu, Yuan Cui, Shijuan Zhu, Xinping
Primary Institution: Capital Medical University, Beijing, People's Republic of China
Hypothesis
Can Trichinella spiralis paramyosin bind to host complement components and protect against host complement attack?
Conclusion
The study suggests that the outer membrane form of T. spiralis paramyosin plays an important role in evading host complement attack.
Supporting Evidence
- Paramyosin was found on the surface of T. spiralis larvae.
- Recombinant paramyosin inhibited complement-mediated lysis of rabbit erythrocytes.
- Blocking paramyosin with specific antibodies reduced the viability of larvae under complement attack.
Takeaway
Trichinella spiralis has a special protein that helps it hide from the body's defenses, allowing it to survive and cause infection.
Methodology
The study used RT-PCR, western blot analysis, immunogold electron microscopy, and functional assays to investigate the binding of paramyosin to complement components.
Statistical Information
P-Value
0.006
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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