Active management of the third stage of labour without controlled cord traction: a randomized non-inferiority controlled trial
2009

Simplified Management of Third Stage of Labour

Sample size: 25000 publication Evidence: high

Author Information

Author(s): Gülmezoglu A Metin, Widmer Mariana, Merialdi Mario, Qureshi Zahida, Piaggio Gilda, Elbourne Diana, Abdel-Aleem Hany, Carroli Guillermo, Hofmeyr G Justus, Lumbiganon Pisake, Derman Richard, Okong Pius, Goudar Shivaprasad, Festin Mario, Althabe Fernando, Armbruster Deborah

Primary Institution: UNDP/UNFPA/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland

Hypothesis

A simplified package comprising oxytocin 10 IU IM/IV (with or without uterine massage) is as effective as the full AMTSL package.

Conclusion

The study aims to determine if a simplified management package for the third stage of labour can reduce blood loss without increasing risks.

Supporting Evidence

  • Active management of the third stage of labour reduces severe postpartum haemorrhage by approximately 60-70%.
  • The study will evaluate whether omitting controlled cord traction affects blood loss.
  • Recruitment will occur in eight countries over a 12-month period.
  • The trial aims to simplify third stage management to improve accessibility in healthcare.

Takeaway

This study is trying to find out if a simpler way to help mothers after giving birth can work just as well as the more complicated method.

Methodology

A hospital-based, multicentre, individually randomized controlled trial.

Participant Demographics

Women delivering vaginally in health facilities across eight countries.

Digital Object Identifier (DOI)

10.1186/1742-4755-6-2

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