Tumor Suppressor p53 Functions as a Negative Regulator in IgE-Mediated Mast Cell Activation
2011
p53's Role in Mast Cell Activation and Allergic Reactions
Sample size: 6
publication
10 minutes
Evidence: high
Author Information
Author(s): Suzuki Kotaro, Murphy Samantha H., Xia Yifeng, Yokota Masaya, Nakagomi Daiki, Liu Fei, Verma Inder M., Nakajima Hiroshi
Primary Institution: Salk Institute for Biological Studies
Hypothesis
p53 functions as a negative regulator in IgE-mediated mast cell activation.
Conclusion
The study shows that p53 inhibits mast cell activation and allergic responses by regulating the NF-κB pathway.
Supporting Evidence
- p53 levels increase upon IgE-mediated activation in mast cells.
- Lack of p53 leads to enhanced mast cell activation and anaphylaxis.
- p53 inhibits IKK2 activity, which is crucial for mast cell degranulation.
- p53 regulates the expression of pro-inflammatory cytokines in mast cells.
- Absence of p53 results in increased O-GlcNAcylation of IKK2.
Takeaway
p53 helps keep mast cells calm during allergic reactions, and without it, they can overreact and cause more problems.
Methodology
The study used various mouse models and assays to analyze mast cell activation and cytokine production.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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