Detection of Somatostatin Receptors in Osteosarcoma
Author Information
Author(s): Ioannou Markos, Papagelopoulos Panayiotis J, Papanastassiou Ioannis, Iakovidou Ioanna, Kottakis Stamatios, Demertzis Nikolaos
Primary Institution: Department of Orthopaedic Surgery, Cancer Hospital, Pireus, Greece
Hypothesis
This study aims to detect somatostatin receptors in human osteosarcomas and correlate this finding with the clinical outcome of the tumour.
Conclusion
The study shows that somatostatin receptors exist in human osteosarcoma, and their presence is associated with aggressive tumor behavior and poor survival rates.
Supporting Evidence
- Four osteosarcomas with aggressive behavior expressed somatostatin receptors.
- Patients with positive somatostatin receptor status had a 0% event-free rate and a 50% overall survival rate at 4.3 years.
- Patients with negative somatostatin receptor status had a 72% event-free survival rate and a 76% overall survival rate at 4.3 years.
Takeaway
The study found that some osteosarcoma tumors have special receptors that can make them grow more aggressively, which means patients with these tumors might not do as well.
Methodology
Immunohistochemical staining was used to detect somatostatin receptors, and survival rates were retrospectively studied in 29 osteosarcoma patients.
Limitations
The small number of specimens analyzed makes statistical analysis unfeasible.
Participant Demographics
14 females and 15 males, average age 27.03 years (range 16–49 years).
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website