Bifidobacterium Strains and Coeliac Disease
Author Information
Author(s): Medina Marcela, De Palma Giada, Ribes-Koninckx Carmen, Calabuig Miguel, Sanz Yolanda
Primary Institution: Instituto de Agroquímica y Tecnología de Alimentos (CSIC)
Hypothesis
Can the faecal microbiota of coeliac patients contribute to the pro-inflammatory environment characteristic of the disease, and can bifidobacteria help mitigate this?
Conclusion
Bifidobacterium strains can suppress the pro-inflammatory effects of the intestinal microbiota in coeliac disease patients.
Supporting Evidence
- Faeces from coeliac patients increased pro-inflammatory cytokine production in immune cells.
- Bifidobacterium strains reduced the inflammatory response induced by coeliac patient faeces.
- Children with active coeliac disease had a different gut microbiota compared to healthy controls.
- Bifidobacterium longum ES1 and B. bifidum ES2 showed potential as probiotics for coeliac disease.
Takeaway
Kids with coeliac disease have a gut that makes them sick, but certain good bacteria can help make it better.
Methodology
The study involved 64 children, including those with active coeliac disease, symptom-free coeliac disease, and healthy controls, assessing the effects of their faecal microbiota on immune responses in vitro.
Potential Biases
Potential bias in patient selection and the influence of dietary factors on microbiota composition.
Limitations
The study was conducted in vitro, which may not fully replicate in vivo conditions.
Participant Demographics
Children aged 1 to 12 years, including 26 with active coeliac disease, 18 symptom-free coeliac disease patients, and 20 healthy controls.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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