Influence of Prior Influenza Vaccination on Antibody and B-Cell Responses
Author Information
Author(s): Sasaki Sanae, He Xiao-Song, Holmes Tyson H., Dekker Cornelia L., Kemble George W., Arvin Ann M., Greenberg Harry B.
Primary Institution: Stanford University School of Medicine
Hypothesis
How does prior influenza vaccination affect serum antibody and B-cell responses to new vaccinations?
Conclusion
The type of vaccine received in the prior year affects the serum antibody and B-cell responses to subsequent vaccination.
Supporting Evidence
- Prior year TIV recipients had significantly higher baseline HAI titers.
- Lower levels of baseline HAI titer were associated with a greater fold-increase of HAI titer after vaccination.
- TIV recipients had greater serum antibody responses than LAIV recipients.
Takeaway
If you got a flu shot last year, it can change how your body reacts to this year's flu vaccine.
Methodology
The study involved 61 healthy adults who were randomized to receive either TIV or LAIV and had their serum antibody and B-cell responses measured at various intervals post-vaccination.
Potential Biases
Potential bias due to the specific age range and health status of participants.
Limitations
The study only included healthy adults aged 22-49 and may not be generalizable to other populations.
Participant Demographics
Healthy adults aged 22-49 years.
Statistical Information
P-Value
p<0.05
Confidence Interval
[24: 14–42]
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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