Mycotoxins and Their Neurotoxic Effects
Author Information
Author(s): Doi Kunio, Uetsuka Koji
Primary Institution: Nippon Institute for Biological Science, The University of Tokyo
Hypothesis
This paper reviews the mechanisms of neurotoxicity induced by various mycotoxins, particularly focusing on oxidative stress-associated pathways.
Conclusion
The study concludes that mycotoxins like T-2 toxin, macrocyclic trichothecenes, fumonisin B1, and ochratoxin A induce neurotoxicity through various mechanisms, including oxidative stress and apoptosis.
Supporting Evidence
- T-2 toxin induces neuronal cell apoptosis in the fetal and adult brain.
- Macrocyclic trichothecenes cause neuronal cell apoptosis and inflammation.
- Fumonisin B1 disrupts de novo ceramide synthesis, leading to neuronal degeneration.
- Ochratoxin A causes acute depletion of striatal dopamine and neuronal cell apoptosis.
Takeaway
Some molds produce toxins that can hurt our brains. This paper talks about how these toxins can make brain cells sick and die.
Methodology
The paper reviews existing studies on the neurotoxic effects of mycotoxins in rodent models and cell cultures.
Limitations
The review primarily focuses on rodent studies, which may not fully represent human responses.
Digital Object Identifier (DOI)
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