2-Deoxy-D-Glucose Treatment and Alzheimer's Disease
Author Information
Author(s): Yao Jia, Chen Shuhua, Mao Zisu, Cadenas Enrique, Brinton Roberta Diaz
Primary Institution: University of Southern California
Hypothesis
Can 2-deoxy-D-glucose (2-DG) sustain mitochondrial function and reduce pathology in a mouse model of Alzheimer's disease?
Conclusion
The study found that 2-DG treatment increased ketogenesis, maintained mitochondrial function, and reduced amyloid pathology in a mouse model of Alzheimer's disease.
Supporting Evidence
- 2-DG diet significantly increased serum ketone body levels.
- 2-DG treatment reduced amyloid precursor protein and amyloid beta oligomers.
- 2-DG increased expression of neurotrophic growth factors BDNF and NGF.
- 2-DG treatment decreased oxidative stress markers.
Takeaway
This study shows that a special diet with 2-DG can help mice with Alzheimer's by giving their brains a different energy source and reducing harmful substances.
Methodology
6-month-old female 3xTgAD mice were fed either a regular diet or a diet containing 0.04% 2-DG for 7 weeks, and various biochemical analyses were performed.
Limitations
The study was conducted in a mouse model, and the applicability to human Alzheimer's disease remains to be determined.
Participant Demographics
6-month-old female 3xTgAD mice
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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