Chicken Cornea as a Model for Wound Healing
Author Information
Author(s): Ritchey Eric R., Code Kimberly, Zelinka Christopher P., Scott Melissa A., Fischer Andy J.
Primary Institution: The Ohio State University
Hypothesis
How does the chicken cornea respond to injury and what are the mechanisms involved in wound healing?
Conclusion
The chick cornea is an excellent model system for studying wound healing, scar tissue formation, and neuronal re-innervation.
Supporting Evidence
- Acute necrotic cell death occurs in the corneal region immediately surrounding the incision.
- Neuronal re-innervation occurs quickly after the initial scarring insult.
- An accumulation of cells within the stroma results from local proliferation of keratocytes.
- Scar-induced accumulations of CD45-positive monocytes are observed in injured corneas.
Takeaway
When a chicken's cornea gets hurt, it heals quickly and grows back new nerves, making it a good model to study how wounds heal.
Methodology
Linear corneal wounds were made in post-natal day 7 chicks, and cellular responses were assessed using immunohistochemical techniques.
Limitations
The study was conducted on young chicks, and responses may differ in older chickens.
Participant Demographics
Post-natal day 7 White Leghorn chickens.
Statistical Information
P-Value
p=0.002
Statistical Significance
p<0.05
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