Study of G+C Content Variations in Human and Mouse Genes
Author Information
Author(s): Nakashima Hiroshi
Primary Institution: Kanazawa University
Hypothesis
The study investigates the characteristics of human and mouse orthologous sequences based on G+C content variations.
Conclusion
The study found that chromosomal locations and rearrangements are associated with G+C content variation between human and mouse sequences.
Supporting Evidence
- The study classified orthologous gene pairs into groups based on G+C content deviations.
- Human and mouse sequences showed distinct nucleotide substitution patterns based on G+C content.
- Chromosomal locations of orthologous genes were found to differ significantly between groups.
Takeaway
Scientists looked at how the DNA of humans and mice is different in terms of G+C content, which is like how much of a certain building block is in their genes. They found that where these genes are located in the DNA can change a lot between the two species.
Methodology
The study analyzed 3,776 pairwise alignments of human and mouse orthologous nucleotide sequences based on G+C content deviations.
Limitations
The study did not explore the functional implications of the observed G+C content variations.
Digital Object Identifier (DOI)
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