Heat Shock Proteins in Gastric Cancer
Author Information
Author(s): Giaginis Constantinos, Daskalopoulou Stella S, Vgenopoulou Stephanie, Sfiniadakis Ioannis, Kouraklis Gregorios, Theocharis Stamatios E
Primary Institution: Medical School, University of Athens, Athens, Greece
Hypothesis
The study aimed to evaluate the clinical significance of HSP -27, -60, and -90 expression in gastric carcinoma.
Conclusion
HSP-27, -60, and -90 were associated with certain clinicopathological parameters crucial for managing gastric adenocarcinoma patients, with HSP-90 expression identified as an independent prognostic indicator.
Supporting Evidence
- HSP-27 expression was significantly associated with tumor size, organ metastases, and pStage.
- HSP-60 expression was significantly associated with patients' sex.
- HSP-90 expression was significantly associated with longer overall survival times.
Takeaway
This study looked at special proteins in stomach cancer and found that one of them, HSP-90, can help doctors understand how long patients might live.
Methodology
The expression of HSP -27, -60, and -90 proteins was assessed immunohistochemically in tumor samples from 66 gastric adenocarcinoma patients.
Participant Demographics
47 men (71%) and 19 women (29%), mean age 67.5 years.
Statistical Information
P-Value
P = 0.026 for HSP-27 with tumor size
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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