New Subtypes in Oesophageal Adenocarcinoma
Author Information
Author(s): Berg Daniela, Wolff Claudia, Langer Rupert, Schuster Tibor, Feith Marcus, Slotta-Huspenina Julia, Malinowsky Katharina, Becker Karl-Friedrich
Primary Institution: Technische Universität München, Munich, Germany
Hypothesis
Can new protein signatures improve therapy selection for oesophageal adenocarcinoma patients?
Conclusion
The study identified a new molecular subtype of oesophageal adenocarcinoma that may lead to targeted treatment options.
Supporting Evidence
- High levels of HER2 and low levels of p-HSP27(Ser15) are linked to poor survival.
- Patients with low HER2 levels had better survival rates.
- Cluster analysis revealed significant differences in metastasis status between patient groups.
Takeaway
Doctors found two new groups of patients with oesophageal cancer based on their proteins, which could help them choose better treatments.
Methodology
The study used reverse phase protein arrays to analyze protein expression in tissue samples.
Limitations
The study's findings need confirmation in independent studies.
Participant Demographics
{"age":{"mean":63,"range":"33–82"},"gender":{"female":8,"male":79}}
Statistical Information
P-Value
0.007
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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