Effects of Prebiotics and Soybean on Colon Cancer Prevention
Author Information
Author(s): Gourineni V. P., Verghese M., Boateng J., Shackelford L., Bhat N. K., Walker L. T.
Primary Institution: Alabama A&M University
Hypothesis
The study aims to evaluate the chemopreventive effects of prebiotics and soybean meal on azoxymethane-induced colon carcinogenesis.
Conclusion
Feeding prebiotics and soybean in combination significantly reduced the incidence of azoxymethane-induced colon tumors.
Supporting Evidence
- Rats fed treatment diets had lower tumor incidence compared to control.
- Combination diets showed smaller tumor sizes and lower tumor numbers.
- Detoxifying enzyme activities were significantly higher in rats fed treatment diets.
Takeaway
This study found that giving rats a mix of prebiotics and soybean helped prevent colon cancer better than just giving them one or the other.
Methodology
Ninety Fisher 344 male rats were divided into nine groups and fed different diets containing prebiotics and soybean meal, followed by azoxymethane injections to induce colon cancer.
Limitations
The study was conducted on rats, which may not fully represent human responses.
Participant Demographics
Fisher 344 male rats, 21 days old at the start of the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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