Dendritic Cells and HIV-1 Trans-Infection
Author Information
Author(s): David McDonald
Primary Institution: Case Western Reserve University School of Medicine
Hypothesis
How do dendritic cells contribute to the transmission of HIV-1 through trans-infection?
Conclusion
Dendritic cells play a critical role in the transmission of HIV-1 by transferring the virus to CD4 T cells without becoming infected themselves.
Supporting Evidence
- Dendritic cells can transfer intact HIV-1 to CD4 T cells through a structure called the infectious synapse.
- Mature dendritic cells have a unique ability to concentrate HIV-1 and facilitate its transmission to T cells.
- Trans-infection by dendritic cells can enhance the spread of HIV-1 in the body.
Takeaway
Dendritic cells can help spread HIV-1 by passing the virus to other immune cells, which can make it harder for the body to fight the virus.
Methodology
This review outlines mechanisms of HIV-1 trans-infection by dendritic cells based on recent data.
Limitations
The review primarily focuses on myeloid dendritic cells and may not cover all aspects of dendritic cell function in HIV-1 transmission.
Digital Object Identifier (DOI)
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