Guards and Culprits in the Endoplasmic Reticulum: Glucolipotoxicity and β-Cell Failure in Type II Diabetes
2012
Glucolipotoxicity and β-Cell Failure in Type II Diabetes
publication
Evidence: moderate
Author Information
Author(s): Karunakaran Udayakumar, Kim Han-Jong, Kim Joon-Young, Lee In-Kyu
Primary Institution: Kyungpook National University School of Medicine
Hypothesis
The endoplasmic reticulum (ER) response to glucotoxicity and lipotoxicity contributes to β-cell dysfunction and death in type II diabetes.
Conclusion
ER stress plays a significant role in β-cell dysfunction and failure during the progression of type II diabetes.
Supporting Evidence
- Chronic exposure to high glucose and fatty acids can lead to β-cell dysfunction and death.
- ER stress is linked to insulin resistance in diabetes.
- Palmitate, a type of fatty acid, is more harmful to β-cells than oleate.
Takeaway
When the body has too much sugar and fat, it can hurt the cells that make insulin, which is important for controlling blood sugar.
Digital Object Identifier (DOI)
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