Eimeria tenella Surface Antigens and Chicken Immune Response
Author Information
Author(s): Chow Yock-Ping, Wan Kiew-Lian, Blake Damer P., Tomley Fiona, Nathan Sheila
Primary Institution: School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia
Hypothesis
The study investigates the role of glycosylphosphatidylinositol-anchored surface antigens (SAGs) of Eimeria tenella in stimulating immune responses in chickens.
Conclusion
Some E. tenella SAGs can modulate chicken innate and humoral immune responses, with certain SAGs linked to increased pathogenicity.
Supporting Evidence
- E. tenella SAGs are expressed during the development of second-generation merozoites.
- Treatment with specific SAGs induced high levels of macrophage nitric oxide production.
- SAGs 4, 5, and 12 suppressed IL-12 and IFN-γ expression while elevating IL-10 levels.
Takeaway
The proteins from a parasite called Eimeria tenella can change how chickens' immune systems react, which might help the parasite survive better.
Methodology
The study involved expressing ten SAGs as recombinant proteins in E. coli, treating chicken macrophages with these proteins, and measuring changes in nitric oxide production and cytokine mRNA expression.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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