Risk Factors for Recurrent Blood Clots in Children with Cerebral Venous Thrombosis
Author Information
Author(s): Kenet Gili MD, Kirkham Fenella Prof MD, Niederstadt Thomas MD, Heinecke Achim PhD, Saunders Dawn MD, Stoll Monika Prof PhD, Brenner Benjamin Prof MD, Bidlingmaier Christoph MD, Heller Christine MD, Knöfler Ralf MD, Schobess Rosemarie MD, Zieger Barbara MD, Sébire Guillaume MD, Nowak-Göttl Ulrike Prof MD
Primary Institution: University Hospital Münster, Germany
Hypothesis
The study investigates the impact of previous diagnoses and hereditary risk factors on the recurrence of venous thrombosis in children.
Conclusion
Age at CVT onset, non-administration of anticoagulation, persistent venous occlusion, and presence of the G20210A mutation in factor II predict recurrent venous thrombosis in children.
Supporting Evidence
- Recurrent venous thrombosis occurred in 22 of 384 surviving children.
- 70% of recurrent events happened within the first 6 months after the initial CVT.
- Children older than 2 years had a higher recurrence rate compared to younger children.
Takeaway
This study found that older children and those not treated with blood thinners after their first blood clot are more likely to have another clot.
Methodology
The study followed 396 children with cerebral venous thrombosis for a median of 36 months to assess recurrence rates and associated risk factors.
Potential Biases
Potential biases due to non-randomization of treatment methods and varying imaging techniques.
Limitations
The study included only data from centers with an interest in pediatric CVT and did not randomize treatment methods.
Participant Demographics
Children aged newborn to 18 years, median age 5.2 years, with 60% being boys.
Statistical Information
P-Value
p<0.0001
Confidence Interval
95% CI 3.4–37.0
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website