Control of Bone Mass and Remodeling by PTH Receptor Signaling in Osteocytes
Author Information
Author(s): O'Brien Charles A., Plotkin Lilian I., Galli Carlo, Goellner Joseph J., Gortazar Arancha R., Allen Matthew R., Robling Alexander G., Bouxsein Mary, Schipani Ernestina, Turner Charles H., Jilka Robert L., Weinstein Robert S., Manolagas Stavros C., Bellido Teresita
Primary Institution: University of Arkansas for Medical Sciences
Hypothesis
Whether hormones influence bone mass or the rate of bone remodeling via actions on osteocytes has heretofore been unknown.
Conclusion
PTH receptor signaling in osteocytes increases bone mass and the rate of bone remodeling through LRP5-dependent and -independent mechanisms.
Supporting Evidence
- Transgenic mice expressing a constitutively active PTH receptor exhibited increased bone mass.
- Deletion of the Wnt co-receptor LRP5 attenuated the high bone mass phenotype.
- PTH receptor signaling in osteocytes increased Wnt signaling and reduced sclerostin expression.
- Increased osteoblast and osteoclast numbers were observed in transgenic mice.
- Bone remodeling was accelerated in transgenic mice with active PTH receptor signaling.
Takeaway
This study shows that a hormone called PTH helps bones grow and stay strong by working on special cells called osteocytes.
Methodology
Transgenic mice expressing a constitutively active PTH receptor were used to study the effects of PTH signaling in osteocytes.
Participant Demographics
Transgenic mice of both sexes were included.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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