Study of MRTX1133 in Rats
Author Information
Author(s): Lu Wei, Zeng Rong, Pan Meng, Zhou Yuan, Tang Huijuan, Shen Wanying, Tang Yijun, Lei Pan
Primary Institution: Hubei University of Medicine
Hypothesis
What are the pharmacokinetics, bioavailability, and tissue distribution of MRTX1133 in rats?
Conclusion
MRTX1133 is quickly absorbed and widely distributed in the main organs, but has very low bioavailability.
Supporting Evidence
- MRTX1133 was quickly absorbed with a peak concentration at 45 minutes after oral administration.
- The plasma half-life of MRTX1133 was 1.12 hours after oral administration.
- MRTX1133 was widely distributed in major organs including liver, kidney, and lung.
- The bioavailability of MRTX1133 was found to be 2.92%.
- 22.59% of MRTX1133 was excreted through the kidneys after 24 hours.
Takeaway
This study looked at how a new drug called MRTX1133 moves through rats' bodies and how much of it gets absorbed. It found that the drug spreads quickly but doesn't stay in the body very long.
Methodology
A UHPLC-MS/MS method was developed to measure MRTX1133 in rat plasma, tissue homogenate, and urine after oral and intravenous administration.
Limitations
Feces were only collected 24 hours after administration, and bile was not collected, limiting the evaluation of excretion routes.
Participant Demographics
45 male Sprague-Dawley rats, weighing 180-220 g.
Digital Object Identifier (DOI)
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