The balance of Polo-like kinase 1 in tumorigenesis
2009
The Role of Polo-like Kinase 1 in Cancer
publication
Evidence: moderate
Author Information
Author(s): Lu Lin-Yu, Yu Xiaochun
Primary Institution: University of Michigan Medical School
Hypothesis
Is the balance of Polo-like kinase 1 (Plk1) crucial for tumorigenesis?
Conclusion
Both overexpression and down-regulation of Plk1 can lead to tumor formation, indicating that its levels must be tightly regulated.
Supporting Evidence
- Plk1 plays a key role in ensuring normal mitosis.
- Overexpression of Plk1 is associated with various cancers.
- Down-regulation of Plk1 can also induce tumor formation.
Takeaway
Polo-like kinase 1 helps cells divide properly, and having too much or too little of it can cause cancer.
Methodology
This review summarizes current understandings of Plk1's role in mitosis and its association with tumorigenesis.
Limitations
The review does not provide original experimental data but summarizes existing literature.
Digital Object Identifier (DOI)
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