Reduced HIV Transmission in Subsequent Pregnancies
Author Information
Author(s): Gumbo Felicity Zvanyadza, Kandawasvika Gwendoline Quintoline, Duri Kerina, Mapingure Munyaradzi Paul, Kurewa Nyaradzai Edith, Nathoo Kusum, Rusakaniko Simbarashe, Chirenje Mike Zvavahera, Stray-Pedersen Babill
Primary Institution: University of Zimbabwe, Harare, Zimbabwe
Hypothesis
What are the HIV transmission rates among mothers who have had multiple pregnancies while enrolled in a PMTCT program?
Conclusion
The study found lower rates of HIV transmission in subsequent pregnancies among women participating in a national PMTCT program.
Supporting Evidence
- 73 children were tested for HIV, with 9 (12.3%) found to be HIV-infected.
- Of the 73 second children, 51 had older siblings with definitive HIV results.
- 33.3% of older siblings were HIV-infected, compared to 12.3% of second children.
Takeaway
Moms with HIV who had more babies after getting treatment passed the virus to fewer of their kids than before.
Methodology
Descriptive cross-sectional study on HIV-infected women enrolled in a PMTCT program, followed for 15 months after delivery.
Potential Biases
Potential bias due to loss to follow-up and incomplete data on initial pregnancies.
Limitations
The study had incomplete follow-up of first pregnancies and some children died before definitive HIV testing.
Participant Demographics
Majority of mothers were married, with an average age of 30.4 years.
Statistical Information
P-Value
0.005
Confidence Interval
95% CI: 4.6–20.1%
Statistical Significance
p=0.005
Digital Object Identifier (DOI)
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