Fgf2's Role in Choroid Plexus Development
Author Information
Author(s): Sarah Greenwood, Adam Swetloff, Angela M Wade, Tetsuya Terasaki, Patrizia Ferretti
Primary Institution: UCL Institute of Child Health
Hypothesis
Does Fgf2 affect the behavior of choroid plexus epithelial cells during development?
Conclusion
Fgf2 is expressed early in choroid plexus development and modulates cell behavior and gene expression, indicating its role in maintaining the integrity of this epithelium.
Supporting Evidence
- Fgf2 is present early in development of the choroid plexus in both mouse and human.
- Fgf2 treatment increases the diameter of choroid plexus vesicles.
- Fgf2 does not increase cell proliferation in vitro.
- Fgf2 regulates expression of transcription factors associated with choroid plexus function.
Takeaway
Fgf2 helps choroid plexus cells stick together and grow, but it doesn't make them multiply faster.
Methodology
Immunohistochemistry was used to study Fgf2 expression, and in vitro models were employed to assess its effects on cell behavior.
Limitations
In vitro models may not fully replicate the complexity of in vivo responses.
Statistical Information
P-Value
p<0.001
Confidence Interval
1.17, 1.20
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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