Toll-Like Receptors and Myocardial Inflammation
2011
Toll-Like Receptors and Myocardial Inflammation
publication
Evidence: high
Author Information
Author(s): Feng Yan, Chao Wei
Primary Institution: Massachusetts General Hospital, Harvard Medical School
Hypothesis
Understanding TLR signaling and their role in cardiovascular diseases may help to identify potential targets for intervention.
Conclusion
Toll-like receptors play a critical role in the pathogenesis of various cardiac conditions, including ischemic myocardial injury, myocarditis, and septic cardiomyopathy.
Supporting Evidence
- TLRs are essential for detecting pathogens and initiating immune responses.
- TLR signaling contributes to myocardial inflammation and injury during ischemia/reperfusion.
- Animal studies show that TLR2 and TLR4 are particularly important in mediating myocardial injury.
Takeaway
Toll-like receptors help our body fight infections and can also cause inflammation in the heart, which can lead to serious heart problems.
Methodology
This paper reviews animal studies on TLRs, their ligands, and the signaling pathways involved in myocardial inflammation.
Digital Object Identifier (DOI)
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