Effects of Gold Nanoparticles on Kidney Tissue
Author Information
Author(s): Abdelhalim Mohamed Anwar K, Jarrar Bashir M
Primary Institution: King Saud University
Hypothesis
The study investigates the particle-size and period effects of gold nanoparticles on renal tissue to address their potential toxicity.
Conclusion
Gold nanoparticles can cause significant histological alterations in renal tissue, with smaller particles inducing more damage.
Supporting Evidence
- Smaller gold nanoparticles caused more significant renal damage compared to larger ones.
- Histological alterations included cloudy swelling, vacuolar degeneration, and nuclear damage.
- The study found that the duration of exposure to gold nanoparticles also influenced the extent of renal injury.
Takeaway
Gold nanoparticles can hurt kidney cells, especially the smaller ones, and the longer they stay, the more damage they can do.
Methodology
70 healthy male Wistar-Kyoto rats were exposed to different sizes and doses of gold nanoparticles for 3 or 7 days to observe renal tissue alterations.
Limitations
The study primarily focused on histological changes without exploring long-term effects or recovery.
Participant Demographics
Healthy male Wistar-Kyoto rats, approximately 12 weeks old, weighing 220-240 grams.
Digital Object Identifier (DOI)
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