Effect of Cistanches Herba Aqueous Extract on Bone Loss in Ovariectomized Rat
2011
Cistanches Herba Extract and Bone Loss in Ovariectomized Rats
Sample size: 32
publication
Evidence: moderate
Author Information
Author(s): Liang Haidong, Yu Fang, Tong Zhihong, Huang Zaiguo
Primary Institution: Dalian Municipal Central Hospital, Dalian University
Hypothesis
Can Cistanches Herba extract prevent bone loss in ovariectomized rats?
Conclusion
Cistanches Herba extract treatment reverses bone loss and prevents osteoporosis in ovariectomized rats.
Supporting Evidence
- Cistanches Herba extract significantly increased bone mineral density and content in ovariectomized rats.
- The extract improved blood antioxidant enzyme activities in the treated rats.
- Treatment with Cistanches Herba extract reduced blood levels of calcium, zinc, and copper in ovariectomized rats.
Takeaway
This study found that a plant extract can help keep bones strong in rats that had their ovaries removed, which usually leads to bone loss.
Methodology
Female Wistar rats were ovariectomized and treated with Cistanches Herba extract for 3 months to assess bone health.
Limitations
Two animals expired during the study, affecting the final sample size.
Participant Demographics
Thirty-two female Wistar rats, aged 3 months.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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