A Novel Role for Mc1r in the Parallel Evolution of Depigmentation in Independent Populations of the Cavefish Astyanax mexicanus
2009
Convergence of Colour Genetics in Cavefish
publication
Evidence: moderate
Author Information
Author(s): Nicholas I. Mundy, Gregory S. Barsh
Primary Institution: University of Cambridge
Hypothesis
What genetic mechanisms underlie the convergent evolution of pigmentation in cavefish?
Conclusion
Different mutations at the same genetic locus, MC1R, are responsible for the parallel evolution of reduced pigmentation in cavefish.
Supporting Evidence
- Different mutations in the MC1R gene lead to similar light coloration in cavefish from different populations.
- MC1R mutations in cavefish also affect eye color, a phenomenon not observed in mammals and birds.
- The study highlights the genetic repeatability of evolution in isolated environments.
Takeaway
Some cavefish have lighter skin and eyes because of changes in a specific gene, and this happens in different caves independently.
Methodology
The study involved QTL mapping and gene knockdown experiments in zebrafish.
Limitations
The study does not address the evolutionary mechanisms behind the observed phenotypes in detail.
Digital Object Identifier (DOI)
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