Kidney Function and Heart Disease Risk
Author Information
Author(s): Emanuele Di Angelantonio, John Danesh, Gudny Eiriksdottir, Vilmundur Gudnason
Primary Institution: University of Cambridge
Hypothesis
This study aims to quantify the association of markers of renal function with coronary heart disease (CHD) risk in apparently healthy adults.
Conclusion
There may be a moderate increase in coronary heart disease risk associated with very low estimated glomerular filtration rate in the general population.
Supporting Evidence
- Individuals with eGFR below 60 ml/min/1.73m2 had a 40% higher risk of developing CHD.
- The study involved a large population-based cohort with a long follow-up period.
- Findings were reinforced by a meta-analysis of six previous studies.
Takeaway
If your kidneys aren't working well, it might make your heart sick too, especially if they're really not working well.
Methodology
The study analyzed data from a population-based cohort in Reykjavik, Iceland, involving 2,007 patients with coronary heart disease and 3,869 controls, calculating estimated glomerular filtration rate (eGFR) from serum creatinine.
Potential Biases
Potential biases were minimized by excluding participants with prevalent diabetes, CHD, and stroke.
Limitations
The study may not generalize to ethnic groups particularly susceptible to impaired renal function.
Participant Demographics
The study included nearly 19,000 middle-aged men and women from Reykjavik, Iceland.
Statistical Information
P-Value
0.02
Confidence Interval
1.01–1.75
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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