Link Between PSMD9 Gene Variants and Hypertension in Type 2 Diabetes Families
Author Information
Author(s): Claudia Gragnoli
Primary Institution: Penn State University and M. S. Hershey Medical Center
Hypothesis
Is the PSMD9 gene linked to elevated blood pressure/hypertension in families with type 2 diabetes?
Conclusion
The PSMD9 gene SNPs are linked to elevated blood pressure/hypertension in Italian families with type 2 diabetes.
Supporting Evidence
- The PSMD9 SNPs IVS3+nt460, IVS3+nt437, and E197G are significantly linked to hypertension.
- The study analyzed 200 Italian families to establish the linkage.
- Both non-parametric and parametric analyses showed significant results.
Takeaway
Scientists found that certain gene changes are connected to high blood pressure in families with diabetes. This helps us understand why some people with diabetes might have high blood pressure.
Methodology
The study involved analyzing 200 Italian families for the presence of specific SNPs and their association with hypertension using non-parametric and parametric linkage analysis.
Limitations
The linkage may capture signals from co-inherited genetic variants related to other phenotypes associated with type 2 diabetes.
Participant Demographics
The study included 928 participants from 200 Italian families, with a near-equal gender distribution.
Statistical Information
P-Value
0.00005
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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