Antifungal Activity of Minimal Domain Peptides from Enterocins
Author Information
Author(s): Cohen Dorrian G., Heidenreich Theresa M., Schorey Jason W., Ross Jessica N., Hammers Daniel E., Vu Henry M., Moran Thomas E., Winski Christopher J., Stuckey Peter V., Ross Robbi L., Yee Elizabeth Arsenault, Santiago-Tirado Felipe H., Lee Shaun W.
Primary Institution: University of Notre Dame
Hypothesis
Can minimal domain peptides derived from enterocins exhibit antifungal activity against clinically relevant fungal strains?
Conclusion
The study found that certain synthetic peptides derived from enterocin AS-48 showed potent antifungal activity against Cryptococcus neoformans and Candida albicans.
Supporting Evidence
- Twelve peptides exhibited antifungal activity against C. neoformans.
- Peptide no. 32 showed inhibitory properties comparable to fluconazole.
- None of the peptides were cytotoxic to human keratinocyte cells.
Takeaway
Scientists created special tiny proteins that can fight off bad fungi, which could help people who get sick from these fungi.
Methodology
The study involved screening a library of synthetic peptides derived from enterocin AS-48 against three fungal strains to assess their antifungal activity and cytotoxicity.
Limitations
The study primarily focused on C. neoformans and did not confirm activity against C. auris.
Statistical Information
P-Value
p<0.05
Digital Object Identifier (DOI)
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