KAP Degradation by Calpain and Its Role in Cyclosporine A-Induced Kidney Injury
Author Information
Author(s): Tornavaca Olga, Sarró Eduard, Pascual Gloria, Bardaji Beatriz, Montero M. Angeles, Salcedo M. Teresa, Plana Maria, López-Hellin Joan, Itarte Emilio, Meseguer Anna
Primary Institution: Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Hypothesis
Low KAP levels found in kidneys of CsA-treated mice might correlate with proximal tubule cell injury.
Conclusion
KAP protects proximal tubule cells from CsA-induced toxicity, suggesting a novel mechanism for CsA-induced kidney toxicity.
Supporting Evidence
- KAP Tg mice showed no increase in kidney injury markers after CsA treatment.
- CK2 inhibition protected against CsA-induced cytotoxicity.
- KAP levels remained stable in CsA-treated Tg mice, unlike control littermates.
Takeaway
KAP is a protein that helps protect kidney cells, and when it's low due to a drug called cyclosporine A, the kidney cells can get hurt.
Methodology
The study used KAP transgenic mice and assessed the effects of cyclosporine A on kidney injury markers.
Participant Demographics
Male KAP-Tg mice and their littermates were used in the study.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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