Methods for Measuring Oxcarbazepine in Pharmaceuticals
Author Information
Author(s): Rajendraprasad Nagaraju, Basavaiah Kanakapura, Vinay Kanakapura B.
Primary Institution: University of Mysore
Hypothesis
Can N-Bromosuccinimide and Bromopyrogallol Red be effectively used to measure oxcarbazepine in pharmaceuticals?
Conclusion
The developed titrimetric and spectrophotometric methods for measuring oxcarbazepine are simple, accurate, and can be applied in routine quality control.
Supporting Evidence
- The titrimetric method allows for the determination of 6–18 mg of oxcarbazepine.
- The spectrophotometric method is applicable over a concentration range of 0.8–8.0 μg mL−1.
- Both methods showed no interference from common pharmaceutical adjuvants.
- Statistical comparison with a reference method indicated no significant difference in accuracy and precision.
Takeaway
This study created two easy ways to check how much oxcarbazepine is in medicine, which is important for making sure the medicine works right.
Methodology
The study used titrimetric and spectrophotometric methods to determine oxcarbazepine levels in pharmaceuticals.
Limitations
The methods may not be applicable to all pharmaceutical formulations and require specific reagents.
Digital Object Identifier (DOI)
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