Cilengitide's Effects on Endothelial and Glioma Cells
Author Information
Author(s): Oliveira-Ferrer Leticia, Hauschild Jessica, Fiedler Walter, Bokemeyer Carsten, Nippgen Johannes, Celik Ilhan, Schuch Gunter
Primary Institution: University Medical Center Hamburg-Eppendorf
Hypothesis
The study investigates the effects of cilengitide on endothelial and glioma cells at molecular and cellular levels.
Conclusion
Cilengitide inhibits integrin-dependent signaling, leading to cellular detachment and apoptosis in both endothelial and glioma cells.
Supporting Evidence
- Cilengitide caused dose-dependent detachment of endothelial cells from culture dishes.
- Cilengitide inhibited proliferation and induced apoptosis in glioma cells with methylated MGMT promotor.
- Cilengitide inhibited phosphorylation of FAK, Src, and Akt in both endothelial and glioma cells.
Takeaway
Cilengitide makes certain cancer cells fall apart and die by stopping them from sticking to their surroundings.
Methodology
The study involved cell culture experiments with human endothelial and glioma cell lines treated with cilengitide, followed by assessments of cell proliferation and apoptosis.
Digital Object Identifier (DOI)
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