Low Dose BPA Affects Social Behavior in Juvenile Mice
Author Information
Author(s): Wolstenholme Jennifer T., Taylor Julia A., Shetty Savera R. J., Edwards Michelle, Connelly Jessica J., Rissman Emilie F.
Primary Institution: University of Virginia School of Medicine
Hypothesis
Does low dose bisphenol A (BPA) exposure during pregnancy affect social behaviors in juvenile mice?
Conclusion
Gestational exposure to low doses of BPA increases social interactions in juvenile female mice.
Supporting Evidence
- BPA exposure increased social interactions in juvenile female mice.
- Females exposed to BPA displayed more side-by-side interactions than control females.
- Males spent more time exploring and sitting alone compared to females.
Takeaway
Mice whose mothers ate a little bit of BPA during pregnancy acted more social when they grew up, especially the girls.
Methodology
Juvenile mice were exposed to low doses of BPA during gestation, and their social interactions were assessed through various behavioral tests.
Potential Biases
Potential bias from the fostering process and the specific strain of mice used.
Limitations
The study focused only on juvenile mice and may not generalize to other ages or species.
Participant Demographics
Juvenile C57BL/6J mice, with 18 females and 21 males exposed to BPA.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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