Influence of Flanking Signals on Signal Peptide Cleavage
Author Information
Author(s): Choo Khar Heng, Ranganathan Shoba
Primary Institution: National University of Singapore
Hypothesis
The study investigates how flanking signal and mature peptide residues affect signal peptide cleavage by SPase I.
Conclusion
The peptide segment recognized by SPase I extends into the mature protein, and the surrounding residues influence cleavage processing.
Supporting Evidence
- The study extracted a large dataset of secretory peptide sequences for analysis.
- Distinctive features in amino acid compositions were observed among eukaryotic and bacterial signal peptides.
- Flanking residues were found to influence the cleavage processing of signal peptides.
Takeaway
This study looks at how certain parts of proteins help them get to the right place in a cell, which is important for making things like medicines.
Methodology
The study analyzed 2352 secretory peptide sequences from various organisms, focusing on their physicochemical properties and amino acid compositions.
Limitations
The study does not account for all possible variations in signal peptide sequences and their effects on cleavage.
Digital Object Identifier (DOI)
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