Genetic Variation in CD-1 Mice
Author Information
Author(s): Aldinger Kimberly A., Sokoloff Greta, Rosenberg David M., Palmer Abraham A., Millen Kathleen J.
Primary Institution: The University of Chicago
Hypothesis
What is the degree of genetic variation present in outbred CD-1 mice?
Conclusion
CD-1 mice exhibit significant genetic variation and population substructure, making them suitable for genetic studies.
Supporting Evidence
- CD-1 mice show patterns of genetic variation similar to those found in human populations.
- Population substructure was identified among CD-1 mice from different breeding facilities.
- CD-1 mice are polymorphic at a significant number of loci.
Takeaway
CD-1 mice are like a big family with lots of different traits, which makes them useful for studying genetics.
Methodology
The study involved genotyping CD-1 mice using various SNP panels to assess genetic diversity and population structure.
Potential Biases
Potential bias due to population substructure among CD-1 mice from different breeding facilities.
Limitations
The SNP panels used were not selected for their informativeness in CD-1 mice, which may have affected the results.
Participant Demographics
CD-1 mice from multiple breeding facilities including North Carolina, Michigan, and New York.
Digital Object Identifier (DOI)
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