Study of B Cell Subsets in Lupus Patients
Author Information
Author(s): Syuichi Koarada, Tada Yoshifumi, Suematsu Rie, Soejima Sachiko, Inoue Hisako, Ohta Akihide, Nagasawa Kohei
Primary Institution: Saga University
Hypothesis
This study aimed to investigate the phenotype of RP105(−) B cell subsets in patients with systemic lupus erythematosus (SLE).
Conclusion
The analysis suggests that RP105(−) B cells are dysregulated in SLE and consist of at least five distinct subsets.
Supporting Evidence
- RP105(−) B cells consist of at least five subsets of late B cells.
- CD19(+)RP105(int) and CD19(low)RP105(−)CD138(int) B cells are significantly larger than other RP105(−) B cell subsets in SLE.
- The percentages of RP105(−) B cell subsets were significantly larger in SLE patients compared to normal subjects.
Takeaway
The study looked at different types of B cells in people with lupus and found that some of these cells are larger and more common in lupus patients than in healthy people.
Methodology
Flow cytometry was used to analyze the phenotypes of RP105(−) B cell subsets in patients with SLE and healthy controls.
Limitations
The study did not explore the functional implications of the identified B cell subsets in SLE.
Participant Demographics
15 patients with active SLE (14 women and 1 man, mean age 41.2 years) and 7 healthy volunteers (6 women and 1 man, mean age 38.2 years).
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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