Portable PET Probes for Tumor Detection During Surgery
Author Information
Author(s): Vivian E. Strong, Charles J. Galanis, Christopher C. Riedl, Valerie A. Longo, Farhad Daghighian, John L. Humm, Steven M. Larson, Yuman Fong
Primary Institution: Memorial Sloan-Kettering Cancer Center
Hypothesis
If shorter range beta emissions are detectable with this novel device, then gamma emissions detected by a hand-held gamma probe should correlate directly with beta emissions from a hand-held beta probe.
Conclusion
The study shows that beta counts may offer superior real-time localization of tumor deposits compared to gamma emissions.
Supporting Evidence
- The portable PET probes detected high-energy gamma and beta emissions from all tumors evaluated.
- There was a strong positive correlation (R = 0.8) between gamma and beta counts.
- Beta emission showed a stronger correlation than gamma emission with overall tissue radioactivity.
Takeaway
This study found a new tool that helps doctors find tumors during surgery by detecting special signals from cancer cells.
Methodology
Mice were injected with tumor cells and imaged using micro-PET; portable PET probes measured gamma and beta emissions.
Limitations
The study has yet to establish the lowest detectable limit in vivo.
Participant Demographics
Six-to-eight-week-old athymic female mice were used in the study.
Statistical Information
P-Value
0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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