How Cell Division Affects HPV Infection
Author Information
Author(s): Pyeon Dohun, Pearce Shane M., Lank Simon M., Ahlquist Paul, Lambert Paul F.
Primary Institution: University of Wisconsin-Madison
Hypothesis
Cell cycle progression through mitosis is critical for HPV infection.
Conclusion
The study concludes that HPV can only establish infection in host cells that are undergoing cell division, specifically during early prophase of mitosis.
Supporting Evidence
- HPV infection requires host cells to be in the M phase of the cell cycle.
- Cell cycle inhibitors were effective in blocking HPV infection.
- Only undifferentiated proliferating cells can be infected by HPV.
Takeaway
HPV needs the host cells to be in a specific stage of division to infect them, like needing a door to be open to get inside a house.
Methodology
The study used chemical biology approaches to test the effects of various cell cycle inhibitors on HPV infection in human keratinocyte cells.
Limitations
The study primarily used immortalized cell lines, which may not fully represent primary keratinocytes in vivo.
Participant Demographics
The study involved human keratinocyte cell lines, specifically 293T and HaCaT cells.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website