Harvey ras Mutations in Head and Neck Cancer
Author Information
Author(s): L.J. Clark, K. Edington, I.R.C. Swan, K.A. McLay, W.J. Newlands, L.C. Wills, H.A. Young, P.W. Johnston, R. Mitchell, G. Robertson, D. Soutar, E.K. Parkinson, G.D. Birniel
Primary Institution: Beatson Institute for Cancer Research
Hypothesis
Are Harvey ras mutations common in squamous cell carcinomas of the head and neck?
Conclusion
Harvey ras mutations are not common in the development or recurrence of squamous cell carcinomas in Caucasian patients.
Supporting Evidence
- No mutations were detected in 6 benign papillomas, 5 erythroplakias, and 56 squamous cell carcinomas.
- Previous studies have shown a low incidence of H-ras mutations in squamous cell carcinoma in Western Europe.
- Mutations were found in 35% of Indian patients with squamous cell carcinoma, suggesting a geographical difference.
Takeaway
The study found that a specific mutation in a gene called Harvey ras is not usually found in throat cancers in white people.
Methodology
The study used polymerase chain reaction (PCR) and direct sequencing to examine tumor samples for mutations.
Limitations
The study may not have examined enough early-stage lesions to fully understand the role of ras mutations.
Participant Demographics
Caucasian patients with squamous cell carcinomas of the head and neck.
Want to read the original?
Access the complete publication on the publisher's website