Inflammatory Cytokine Profiles During Exercise in Obese, Diabetic, and Healthy Children
Author Information
Author(s): Galassetti Pietro R., Rosa Jaime S., Heydari Shirin, Oliver Stacy R., Flores Rebecca L., Pontello Andria M., Ibardolaza Milagros
Primary Institution: University of California, Irvine, CA, USA
Hypothesis
The balance between pro- and anti-inflammatory mediators during exercise may be altered in children with obesity and type 1 diabetes, affecting their health outcomes.
Conclusion
Obese and type 1 diabetic children show exaggerated pro-inflammatory responses during exercise compared to healthy children.
Supporting Evidence
- Obese children had significantly higher levels of TNF-a and IL-2 compared to type 1 diabetic and healthy children.
- All 8 tested cytokines were elevated in obese children compared to healthy controls.
- Type 1 diabetic children showed intermediate levels of inflammatory markers between obese and healthy children.
Takeaway
When kids who are overweight or have diabetes exercise, their bodies react with more inflammation than kids who are healthy.
Methodology
The study monitored the levels of 8 inflammatory cytokines during a standardized exercise challenge in three groups: obese, type 1 diabetic, and healthy children.
Potential Biases
Potential bias in cytokine measurement methods and participant selection.
Limitations
The study may not account for all variables affecting inflammatory responses, and the sample size is limited to three specific groups.
Participant Demographics
23 obese children (12 females, 11 males), 23 type 1 diabetic children (10 females, 13 males), and 20 healthy children (10 females, 10 males).
Statistical Information
P-Value
p<0.0167
Statistical Significance
p<0.0167
Digital Object Identifier (DOI)
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