Predictors of Impaired Glucose Regulation in Patients with Non-Alcoholic Fatty Liver Disease
Author Information
Author(s): Hatziagelaki Erifili, Karageorgopoulos Drosos E., Chounta Athina, Tsiavou Anastasia, Falagas Matthew E., Dimitriadis George
Primary Institution: University of Athens Medical School, Attikon University Hospital
Hypothesis
What characteristics of NAFLD patients are associated with hyperglycemia?
Conclusion
NAFLD patients with higher BMI, lower HDL-C, or older age were more likely to have impaired glucose metabolism.
Supporting Evidence
- 48.7% of NAFLD patients had hyperglycemia.
- Age, BMI, and HDL-C were independent predictors of hyperglycemia.
- Patients with hyperglycemia had lower insulin levels at 30 minutes after glucose load.
Takeaway
Doctors found that many people with a liver problem called NAFLD also have issues with their blood sugar. If you're older, heavier, or have low good cholesterol, you might need a special test to check your blood sugar.
Methodology
152 NAFLD patients underwent a 2-hour oral glucose tolerance test to measure serum glucose and insulin.
Potential Biases
Potential selection bias as patients were recruited from a single outpatient clinic.
Limitations
The study was limited to a specific cohort and may not be generalizable to all populations.
Participant Demographics
152 Caucasian patients (52% females, 48% males) with a mean age of 50.1 years.
Statistical Information
P-Value
0.02
Confidence Interval
1.03–1.13 for age, 1.01–1.25 for BMI, 0.92–0.98 for HDL-C
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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