The Role of LSR in Bladder Cancer Cell Invasion and Motility
Author Information
Author(s): Malene Herbsleb, Karin Birkenkamp-Demtroder, Thomas Thykjaer, Carsten Wiuf, Anne-Mette K Hein, Torben F Ørntoft, Lars Dyrskjøt
Primary Institution: Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital
Hypothesis
What is the role of lipolysis stimulated lipoprotein receptor (LSR) in bladder cancer cell motility and invasion?
Conclusion
LSR may impair bladder cancer cells from gaining invasive properties.
Supporting Evidence
- Knockdown of LSR increased invasion capacity by 3-fold in bladder cancer cells.
- After 48 hours, motility capacity was significantly increased 3.5-fold in LSR-siRNA transfected cells.
- Gene networks related to cancer and cellular movement were identified as significantly overrepresented.
Takeaway
Scientists studied a protein called LSR in bladder cancer cells and found that when they reduced LSR, the cells moved and invaded more easily.
Methodology
The study used siRNA knockdown experiments and microarray analysis to investigate gene expression changes in bladder cancer cells.
Statistical Information
P-Value
p < 0.02
Statistical Significance
p<0.004
Digital Object Identifier (DOI)
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