The Role of B Cells and Immunoglobulins in Multiple Sclerosis
Author Information
Author(s): Wootla Bharath, Denic Aleksandar, Keegan B. Mark, Winters Jeffrey L., Astapenko David, Warrington Arthur E., Bieber Allan J., Rodriguez Moses
Primary Institution: Mayo Clinic
Hypothesis
How do B cells contribute to the pathogenesis of multiple sclerosis?
Conclusion
Immunoglobulins have both detrimental and beneficial roles in multiple sclerosis, influencing disease progression and potential recovery.
Supporting Evidence
- Approximately 400,000 people have been diagnosed with MS in the United States.
- 40% of patients with acute neurological deficits showed dramatic recovery following plasma exchange.
- 59% of patients demonstrated moderate to marked functional neurological improvement within 6 months after plasma exchange.
Takeaway
B cells can help or hurt people with multiple sclerosis; sometimes they make the disease worse, but other times they help repair damage.
Methodology
The study involved a review of existing literature and clinical trials related to B cells and immunoglobulins in multiple sclerosis.
Potential Biases
Potential biases may arise from the reliance on existing studies and the variability in patient responses to treatments.
Limitations
The study highlights the complexity of multiple sclerosis and the need for individualized treatment approaches.
Participant Demographics
The study references a population of multiple sclerosis patients, including those with acute, steroid-refractory CNS inflammatory demyelinating disease.
Statistical Information
P-Value
0.046
Statistical Significance
p=0.046
Digital Object Identifier (DOI)
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