Effects of Ocimum sanctum Leaf Extracts on Cholesterol in Rats
Author Information
Author(s): Thamolwan Suanarunsawat, Devakul Na Ayutthaya, Watcharaporn Songsak, Thirawarapan Suwan, Poungshompoo Somlak
Primary Institution: Rangsit University
Hypothesis
The study investigates the lipid-lowering and antioxidative activities of Ocimum sanctum leaf extracts in rats fed a high-cholesterol diet.
Conclusion
Ocimum sanctum leaf extracts decreased serum and hepatic lipid levels and provided protection to liver and cardiac tissues from hypercholesterolemia.
Supporting Evidence
- Ocimum sanctum extracts significantly decreased serum total cholesterol, triglycerides, and LDL-C levels.
- The extracts increased fecal bile acids excretion without affecting fecal lipid excretion.
- Histopathological analysis showed improved liver and cardiac tissue morphology in treated rats.
Takeaway
This study found that a plant called Ocimum sanctum can help lower bad fats in the blood and protect the heart and liver in rats that eat a lot of cholesterol.
Methodology
Rats were divided into three groups: normal diet, high-cholesterol diet, and high-cholesterol diet with Ocimum sanctum extracts administered for three weeks.
Limitations
The study was conducted on rats, and results may not directly translate to humans.
Participant Demographics
Male Wistar rats weighing between 90–120 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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