Cross-Protective Potential of a Novel Monoclonal Antibody Against Influenza A Viruses
Author Information
Author(s): Yoshida Reiko, Igarashi Manabu, Ozaki Hiroichi, Kishida Noriko, Tomabechi Daisuke, Kida Hiroshi, Ito Kimihito, Takada Ayato
Primary Institution: Hokkaido University Research Center for Zoonosis Control
Hypothesis
Can a novel monoclonal antibody provide heterosubtypic immunity to influenza A viruses?
Conclusion
The monoclonal antibody MAb S139/1 can neutralize multiple subtypes of influenza A viruses and provides heterosubtypic protection in mice.
Supporting Evidence
- MAb S139/1 showed broad reactivity to various influenza A virus strains.
- Passive immunization with MAb S139/1 provided significant protection in mice.
- Mutant viruses that escaped neutralization by MAb S139/1 were identified.
- Sequence analysis revealed key amino acid substitutions in escape mutants.
- MAb S139/1 inhibited viral attachment to cells.
- The study supports the role of cross-reactive antibodies in heterosubtypic immunity.
Takeaway
Scientists created a special antibody that can help protect against different types of the flu virus, like a superhero for your immune system.
Methodology
The study involved generating a monoclonal antibody, testing its reactivity against various influenza A virus strains, and evaluating its protective efficacy in mice.
Limitations
The antibody's neutralization activity was not linked to protective potential against all strains.
Participant Demographics
Mice were used for testing the antibody's efficacy.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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