Silibinin and Its Effects on Pancreatic Cancer Cells
Author Information
Author(s): Ge Yakun, Zhang Yuanxin, Chen Yunpeng, Li Quanshun, Chen Jun, Dong Ying, Shi Wei
Primary Institution: Key Laboratory for Molecular Enzymology & Engineering of the Ministry of Education, School of Life Science, Jilin University
Hypothesis
Can Silibinin inhibit the growth of human pancreatic carcinoma cells and what are the underlying mechanisms?
Conclusion
Silibinin effectively inhibited the proliferation of pancreatic carcinoma cells and induced apoptosis, particularly in AsPC-1 cells.
Supporting Evidence
- Silibinin inhibited the proliferation of AsPC-1, Panc-1, and BxPC-3 cells in a dose- and time-dependent manner.
- Silibinin induced apoptosis in AsPC-1, Panc-1, and BxPC-3 cells.
- Cell cycle analysis showed that Silibinin caused G1 phase arrest in AsPC-1 cells.
Takeaway
Silibinin is a substance that can help stop cancer cells in the pancreas from growing and can make them die.
Methodology
The study evaluated the effects of Silibinin on pancreatic cancer cell lines using dose escalation experiments, apoptosis detection, and cell cycle analysis.
Limitations
The study primarily focused on three pancreatic cancer cell lines, which may not represent all pancreatic cancer types.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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