Urinary Eosinophil Protein X in Children with Atopic Asthma
Author Information
Author(s): M. Nuijsink, W. C. J. Hop, P. J. Sterk, E. J. Duiverman, P. S. Hiemstra, J. C. de Jongste
Hypothesis
Measuring EPX in urine could potentially prove to be useful for monitoring eosinophilic airway inflammation in children.
Conclusion
uEPX/c levels did not correlate with established markers of asthma severity and eosinophilic airway inflammation in atopic asthmatic children.
Supporting Evidence
- uEPX/c showed a log-normal distribution, median 185 μg/mmol creatinine.
- There was a significant inverse correlation of uEPX/c with FEV1 (r = −.18, P = .02).
- uEPX/c did not correlate with symptom scores or inhaled steroid dose.
Takeaway
The study looked at a protein in urine to see if it could help understand asthma in kids, but it didn't really show a clear connection.
Methodology
A cross-sectional study was performed measuring urinary eosinophil protein X in 180 steroid-dependent atopic children with asthma.
Limitations
The study had a small number of children for some measurements, and urine samples were not all collected at the same time of day.
Participant Demographics
Median age 10.3 years (range 6–16 years), 58.3% boys.
Statistical Information
P-Value
0.01
Confidence Interval
95% CI: 5,30%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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